Cooking a delicious meatloaf can be an enjoyable and rewarding experience, especially if you follow the right steps. If you want to get it just right – juicy on the inside and beautifully golden brown on the outside – then knowing how long to cook a meatloaf at 375 is essential. In this blog post, we will provide step-by-step instructions for getting your next meal of homemade meatloaf cooked perfectly, with tips and tricks along the way that will help make sure it comes out looking and tasting exactly as you intend!
Contents
- 1 What Is Meatloaf?
- 2 Is Meatloaf Goof For You?
- 3 Ingredients Needed To Cook Meatloaf
- 4 How To Cook Meatloaf At 375 From Scratch?
- 5 How Long To Cook Meatloaf At 375?
- 6 Factors Affect To The Time To Cook Meatloaf At 375
- 7 Why Should You Know How Long To Cook Meatloaf At 375?
- 8 Tips For Making The Perfect Meatloaf At 375
- 9 How Do I Know When A Meatloaf Is Cooked?
- 10 What Temperature Should Meatloaf Be Cooked At?
- 11 Should You Cook Meatloaf Covered Or Uncovered?
- 12 What To Serve With Meatloaf?
- 13 Conclusion: How Long To Cook Meatloaf At 375?
- 14 FAQ: Cook Meatloaf At 375
- 14.1 How long do you cook a 2lb meatloaf at 375?
- 14.2 What temp is meatloaf done in Celsius?
- 14.3 Is it OK if my meatloaf is a little pink?
- 14.4 How long does it take to cook meatloaf at 400?
- 14.5 Can I cook meatloaf at 200 degrees?
- 14.6 What temp should meatloaf be cooked in Celsius?
- 14.7 Is it better to cook meatloaf at 350 or 375?
- 14.8 What is the secret to moist meatloaf?
- 14.9 Does meatloaf continue to cook while resting?
- 14.10 Should I cover meatloaf when baking?
- 14.11 What is the perfect temperature for meatloaf?
- 14.12 How do you not overcook meatloaf?
- 14.13 Why do you put milk in meatloaf?
What Is Meatloaf?
Before we get into the details of how long to cook a meatloaf at 375, let’s start by looking at what it is. Meatloaf is a savory dish that typically consists of ground beef, pork, or lamb mixed with various ingredients such as breadcrumbs, onion, garlic, and herbs. The mixture is then shaped into a loaf-like shape and baked in the oven. It can be served either hot or cold, but it tastes best when freshly cooked.

Is Meatloaf Goof For You?
Yes! Not only is it delicious, but meatloaf is actually a very healthy meal option. It’s packed with protein and essential vitamins and minerals that are vital for good health such as iron, zinc, potassium, and magnesium. Additionally, if you use lean ground beef in your recipe then the fat content of the dish will be lower than other similarly-sized portions of other meats, making it a healthier choice.
Ingredients Needed To Cook Meatloaf
In addition to the ground beef, you will need some other ingredients in order to cook a meatloaf. These include:
- Breadcrumbs or cracker crumbs
- A beaten egg (or an egg substitute)
- Onion
- Garlic
- Spices and herbs such as oregano, parsley, thyme, and basil
- Ketchup
- Worcestershire sauce
You may also want to add other ingredients such as grated cheese or diced peppers for extra flavor.

How To Cook Meatloaf At 375 From Scratch?
Cooking homemade meatloaf at 375 degrees is easy and can be done with just a few simple steps.
- Preheat your oven to 375°F (190°C).
- Mix all of the ingredients together in a large bowl until well combined.
- Grease the loaf pan using butter or oil, then press the mixture into the pan.
- Place the loaf pan in the oven and cook for approximately 45 minutes, or until an internal temperature of 165°F (74°C) is reached.
- Let your meatloaf rest for 10 minutes after removing it from the oven before serving.
How Long To Cook Meatloaf At 375?
The exact cooking time of your meatloaf will depend on the size of your loaf and the ingredients you used. As a general rule, it should take approximately 45 minutes to cook a meatloaf at 375°F (190°C). However, it’s always best to use a food thermometer to make sure that an internal temperature of 165°F (74°C) is reached before serving. This will ensure that your meatloaf is cooked through and safe to eat.
Let’s watch this video to know more about how long to cook a meatloaf at 375.
Factors Affect To The Time To Cook Meatloaf At 375
There are several factors that can affect the cooking time of your meatloaf. These include:
- The size and shape of your loaf; a larger or thicker loaf will take longer to cook than a smaller one.
- The type of ground beef you use; leaner ground beef takes less time to cook than fattier cuts.
- The amount of moisture in your ingredients; if you add wet ingredients like diced tomatoes or grated cheese, they will release moisture and increase the cooking time.
Why Should You Know How Long To Cook Meatloaf At 375?
Knowing how long to cook a meatloaf at 375 is essential if you want to get the perfect meal. If your meatloaf is undercooked, it can be unsafe to eat as there may still be harmful bacteria present in the uncooked meat. On the other hand, if it’s overcooked then it will be dry and tough instead of juicy and tender. By following the steps above and using a food thermometer to make sure your meatloaf is cooked through, you can be sure that it will come out perfectly every time!

Tips For Making The Perfect Meatloaf At 375
Now that you know more about how long to cook a meatloaf at 375, let’s explore tips to make it more attractive.
- Choose leaner ground beef for a healthier dish.
- Use a combination of spices and herbs to add flavor to your meatloaf.
- To give it an extra boost of flavor, glaze the top with ketchup or barbecue sauce during the last 10 minutes of cooking time.
- Let your meatloaf rest for at least 10 minutes after removing it from the oven, as this will help to keep it juicy.
- Make sure to use a food thermometer to check the internal temperature of your meatloaf before serving.

How Do I Know When A Meatloaf Is Cooked?
One of the easiest ways to tell if your meatloaf is cooked through is by using a food thermometer. Insert it into the thickest part of the loaf and check that the internal temperature has reached 165°F (74°C). If it’s not quite done yet, put it back in the oven for a few more minutes and then check again. You can also tell if it’s cooked through by cutting into it; the meat should be a light pink color throughout and the juices should run clear. As always, use your best judgement when assessing your food for doneness.
What Temperature Should Meatloaf Be Cooked At?
For a perfect meatloaf, you’ll want to cook it at 375°F (190°C) in your oven. This temperature will ensure that the meat is cooked through and remains juicy on the inside while becoming beautifully golden brown on the outside. Remember to use a food thermometer to check the internal temperature of your meatloaf in order to be sure it’s cooked through before serving.

Should You Cook Meatloaf Covered Or Uncovered?
You should cook your meatloaf uncovered in the oven. Covering it will trap moisture inside, which can prevent the outside of the loaf from becoming golden brown and crispy. If you want to add extra flavor or moisture to your meatloaf, try brushing some ketchup or Worcestershire sauce over the surface about halfway through cooking.
What To Serve With Meatloaf?
Meatloaf is a classic comfort food that pairs well with many sides. Some of the most popular side dishes to serve alongside meatloaf include mashed potatoes, roasted vegetables, macaroni and cheese, corn on the cob, and coleslaw. For an ultra-comforting meal you can also try serving it with biscuits or dinner rolls. Whatever your preference, there’s sure to be something that goes perfectly with your homemade meatloaf! To keep your meatloaf moist, try adding wet ingredients like diced tomatoes or grated cheese to the mixture.
You can also brush some ketchup or Worcestershire sauce over the top of your meatloaf about halfway through cooking to add extra moisture and flavor. If you want to add an extra layer of flavor and texture, top your meatloaf with sliced bacon or crushed crackers before baking it in the oven. Finally, make sure to let your finished meatloaf rest for at least 10 minutes after removing it from the oven, as this will help keep all that juicy goodness locked inside!

Conclusion: How Long To Cook Meatloaf At 375?
So we have answered the question how long to cook a meatloaf at 375. Cooking a delicious, juicy meatloaf at 375°F (190°C) is easy and can be done in just a few simple steps. It should take approximately 45 minutes to cook an average-sized loaf of meat at this temperature, but it’s always best to use a food thermometer to make sure the internal temperature reaches 165°F (74°C) before serving. For extra flavor, try adding ketchup or Worcestershire sauce during the last ten minutes of cooking, and let your meatloaf rest for at least 10 minutes after removing it from the oven. Thank you for reading at johnnygrits.com.
FAQ: Cook Meatloaf At 375
How long do you cook a 2lb meatloaf at 375?
To achieve the perfect meatloaf, it’s important to know the appropriate cooking time. A 1-pound meatloaf needs 35-45 minutes in the oven, while a 2-pound meatloaf requires approximately an hour. If you’re cooking a 3-pound meatloaf, plan for 1 ½ to 2 hours of baking time.
What temp is meatloaf done in Celsius?
Don’t worry, we’ve got you covered. Season your loaf and add your favorite veggies, then be sure to use an accurate thermometer to achieve the best results. You’ll know it’s cooked through when it reaches 160°F (71°C).
Is it OK if my meatloaf is a little pink?
Ensure your ground beef patty or meatloaf reaches the safe temperature of 160 F (71 C) for optimal safety, regardless of its color. Don’t rely on appearance alone – prioritize thorough cooking for your well-being.
How long does it take to cook meatloaf at 400?
Cooking meatloaf at 400 degrees F takes approximately 45-50 minutes. Achieve a mouthwatering result by preheating your oven to the recommended temperature and ensuring the internal temperature reaches 165. Afterward, allow the meatloaf to rest before indulging in this beloved American classic. Enjoy a scrumptious meal in under an hour with minimal exertion.
Can I cook meatloaf at 200 degrees?
Achieve a mouthwatering meatloaf by cooking it at 200 degrees Fahrenheit. Enhance the flavor by using indirect heat on a covered grill. Monitor the internal temperature with an instant-read thermometer, removing it from the heat once it reaches a delectable 140F. Enjoy a perfectly cooked dinner with this simple method.
What temp should meatloaf be cooked in Celsius?
Achieve the utmost tenderness and flavor throughout your meatloaf by aiming for an internal temperature of 70 degrees Celsius (160 degrees Fahrenheit). Your taste buds will certainly appreciate it.
Is it better to cook meatloaf at 350 or 375?
For the most delicious meatloaf, set your oven to 350 degrees F. This will prevent drying out and provide an optimal flavor experience.
What is the secret to moist meatloaf?
Discover the key to perfectly moist meatloaf by enhancing its flavor and succulent juiciness at every stage of the recipe. From incorporating eggs and ketchup to adding tomato paste, mustard, Worcestershire sauce, or even barbecue sauce, infusing these elements will create a mouthwatering sensation that is impossible to resist.
Does meatloaf continue to cook while resting?
After it’s taken out, the dish continues to cook internally through a process known as “carryover cooking”. This leads to an increase in temperature of up to 5 degrees, resulting in that iconic hot and juicy treat that everyone adores.
Should I cover meatloaf when baking?
For an irresistibly succulent meatloaf, it’s crucial to bake it uncovered. But fret not if you’re concerned about browning or burning – simply cover it with foil for 45 minutes, preserving its glorious golden hue. Then, unveil your masterpiece and continue baking, uncovered, for an additional 15 minutes, allowing the top to acquire a luscious color.
What is the perfect temperature for meatloaf?
Cooking the perfect meatloaf requires precision. Your thermometer should read 160°F for a fully-cooked center, or try an oven-safe thermometer to track progress during baking.
How do you not overcook meatloaf?
Achieving culinary perfection with meatloaf calls for exactness. Ensure a fully-cooked center by using a thermometer that registers 160°F, or employ an oven-safe thermometer to monitor progress while it bakes.
Why do you put milk in meatloaf?
Discover the secret to mouthwatering meatloaf that remains irresistibly moist throughout. Incorporating milk into your recipe not only guarantees its delectable taste, but also ensures its juicy texture. For those seeking alternatives, consider exploring low-sodium beef stock, hearty chicken stock, or even delightful non-dairy milk substitutes. Elevate your meatloaf game with these simple yet effective enhancements.

Christopher Muller is the co-owner and executive chef for Johnny Grits, a charming southern restaurant in Tarpon Springs. With a passion for freshly made classic southern meals, he puts innovation and creativity into every dish that comes out of his kitchen. He has created innovative recipes like the signature “grit skillet sides,” which include savory ingredients folded into delicious grits such as bacon and blue cheese, three-cheese, mushrooms and Swiss cheese, or sautéed mushrooms with truffle oil. Christopher’s drive to bring new flavors to traditional dishes makes Johnny Grits an exciting place to enjoy a meal.
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